Systems Modelling of NHEJ Reveals the Importance of Redox Regulation of Ku70/80 in the Dynamics of DNA Damage Foci

Open Access

Peer-reviewed

Research Article

David Dolan,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Glyn Nelson,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Anze Zupanic,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Graham Smith,

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯
Daryl Shanley

* E-mail: daryl.shanley@ncl.ac.uk

Affiliation Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, United Kingdom
⨯

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DNA repair
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Non-homologous end joining
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DNA damage
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Cysteine
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DNA-binding proteins
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Chemical dissociation
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Oxidation-reduction reactions
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Redox signaling
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