Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection

Krishna P. Kota; Brett Eaton; Douglas Lane; Melanie Ulrich; Ricky Ulrich; Brian D. Peyser; Camenzind G. Robinson; James G. Jaissle; Gianluca Pegoraro; Sina Bavari; Rekha G. Panchal

doi:10.1371/journal.pone.0055167

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Open Access

Peer-reviewed

Research Article

Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection

Krishna P. Kota,

Affiliation Perkin Elmer, Waltham, Massachusetts, United States of America
⨯
Brett Eaton,

Affiliation Department of Target Discovery and Cellular Microbiology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Douglas Lane,

Affiliation Target Structure Based Drug Discovery Group, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Melanie Ulrich,

Affiliation Department of Target Discovery and Cellular Microbiology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Ricky Ulrich,

Affiliation Department of Target Discovery and Cellular Microbiology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Brian D. Peyser,

Affiliation Target Structure Based Drug Discovery Group, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, United States of America
⨯
Camenzind G. Robinson,

Affiliation Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
James G. Jaissle,

Affiliation Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
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Gianluca Pegoraro,

Affiliation Perkin Elmer, Waltham, Massachusetts, United States of America
⨯
Sina Bavari,

Affiliation Department of Target Discovery and Cellular Microbiology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯
Rekha G. Panchal

* E-mail: rekha.panchal@amedd.army.mil

Affiliation Department of Target Discovery and Cellular Microbiology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
⨯

Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection

Krishna P. Kota,
Brett Eaton,
Douglas Lane,
Melanie Ulrich,
Ricky Ulrich,
Brian D. Peyser,
Camenzind G. Robinson,
James G. Jaissle,
Gianluca Pegoraro,
Sina Bavari

Published: January 30, 2013
https://doi.org/10.1371/journal.pone.0055167

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