Biapenem Inactivation by B2 Metallo β-Lactamases: Energy Landscape of the Hydrolysis Reaction

Open Access

Peer-reviewed

Research Article

Sharon H. Ackerman,

Affiliation Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
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Domenico L. Gatti

* E-mail: dgatti@med.wayne.edu

Affiliations Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Cardiovascular Research Institute, Wayne State University School of Medicine, Detroit, Michigan, United States of America
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Enzymes
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Enzyme structure
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Hydrolysis
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Free energy
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Protons
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Zinc
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Reactants
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Hydrogen bonding
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