Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

Kazuhiro Nakaso; Naoko Tajima; Satoru Ito; Mari Teraoka; Atsushi Yamashita; Yosuke Horikoshi; Daisuke Kikuchi; Shinsuke Mochida; Kenji Nakashima; Tatsuya Matsura

doi:10.1371/journal.pone.0055068

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Open Access

Peer-reviewed

Research Article

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

Kazuhiro Nakaso ,

* E-mail: kazuhiro@med.tottori-u.ac.jp

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Naoko Tajima,

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Satoru Ito,

Affiliation Division of Neurology, Department of Brain and Neurosciences, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Mari Teraoka,

Affiliations Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan, Division of Emergency and Disaster Medicine, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Atsushi Yamashita,

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Yosuke Horikoshi,

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Daisuke Kikuchi,

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Shinsuke Mochida,

Affiliation Division of Anesthesiology and Critical Medicine, Department of Surgery, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Kenji Nakashima,

Affiliation Division of Neurology, Department of Brain and Neurosciences, Tottori University Faculty of Medicine, Yonago, Japan
⨯
Tatsuya Matsura

Affiliation Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, Tottori University Faculty of Medicine, Yonago, Japan
⨯

Dopamine-Mediated Oxidation of Methionine 127 in α-Synuclein Causes Cytotoxicity and Oligomerization of α-Synuclein

Kazuhiro Nakaso,
Naoko Tajima,
Satoru Ito,
Mari Teraoka,
Atsushi Yamashita,
Yosuke Horikoshi,
Daisuke Kikuchi,
Shinsuke Mochida,
Kenji Nakashima,
Tatsuya Matsura

Published: February 14, 2013
https://doi.org/10.1371/journal.pone.0055068

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Methionine
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Parkinson disease
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Cytotoxicity
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Dopamine
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Oxidation
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Oligomers
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