Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Devika P. Bagchi; Lihai Yu; Joel S. Perlmutter; Jinbin Xu; Robert H. Mach; Zhude Tu; Paul T. Kotzbauer

doi:10.1371/journal.pone.0055031

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Research Article

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Devika P. Bagchi,

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Lihai Yu,

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Joel S. Perlmutter,

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Program in Occupational Therapy, and Washington University School of Medicine, St. Louis, Missouri, United States of America, Program in Physical Therapy, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Jinbin Xu,

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Robert H. Mach,

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Zhude Tu,

Affiliations Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
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Paul T. Kotzbauer

* E-mail: kotzbauerp@neuro.wustl.edu

Affiliations Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

Devika P. Bagchi,
Lihai Yu,
Joel S. Perlmutter,
Jinbin Xu,
Robert H. Mach,
Zhude Tu,
Paul T. Kotzbauer

Published: February 6, 2013
https://doi.org/10.1371/journal.pone.0055031

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