Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS

Bo Ma; Jiannan Liu; Qi Zhang; Hanjie Ying; Jiye A; Jianguo Sun; Di Wu; Yonglu Wang; Jing Li; Yinhui Liu

doi:10.1371/journal.pone.0054965

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Open Access

Peer-reviewed

Research Article

Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS

Bo Ma ,

Contributed equally to this work with: Bo Ma, Jiannan Liu

Affiliation School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯
Jiannan Liu ,

Contributed equally to this work with: Bo Ma, Jiannan Liu

Affiliation Department of Respiration, Jiangsu Geriatric Hospital, Nanjing, People’s Republic of China
⨯
Qi Zhang ,

* E-mail: nancyzhang03@hotmail.com (QZ); yinghanjie134@163.com (HY)

Affiliation School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯
Hanjie Ying ,

* E-mail: nancyzhang03@hotmail.com (QZ); yinghanjie134@163.com (HY)

Affiliation School of Life Science and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯
Jiye A,

Affiliation Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People’s Republic of China
⨯
Jianguo Sun,

Affiliation Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, People’s Republic of China
⨯
Di Wu,

Affiliations Laboratory for Systems Biology, Division of Clinical Pharmacology and Therapeutics, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Kinetic Modeling and Simulation (KMAS) Core, Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Yonglu Wang,

Affiliation School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯
Jing Li,

Affiliation School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯
Yinhui Liu

Affiliation School of Pharmaceutical Sciences, Nanjing University of Technology, Nanjing, People’s Republic of China
⨯

Metabolomic Profiles Delineate Signature Metabolic Shifts during Estrogen Deficiency-Induced Bone Loss in Rat by GC-TOF/MS

Bo Ma,
Jiannan Liu,
Qi Zhang,
Hanjie Ying,
Jiye A,
Jianguo Sun,
Di Wu,
Yonglu Wang,
Jing Li,
Yinhui Liu

Published: February 7, 2013
https://doi.org/10.1371/journal.pone.0054965

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Osteoporosis
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Estrogens
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Metabolomics
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