Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice

Catalina Atorrasagasti; Estanislao Peixoto; Jorge B. Aquino; Néstor Kippes; Mariana Malvicini; Laura Alaniz; Mariana Garcia; Flavia Piccioni; Esteban J. Fiore; Juan Bayo; Ramón Bataller; Elizabeth Guruceaga; Fernando Corrales; Osvaldo Podhajcer; Guillermo Mazzolini

doi:10.1371/journal.pone.0054962

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Peer-reviewed

Research Article

Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice

Catalina Atorrasagasti,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Estanislao Peixoto ,

Contributed equally to this work with: Estanislao Peixoto, Jorge B. Aquino

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Jorge B. Aquino ,

Contributed equally to this work with: Estanislao Peixoto, Jorge B. Aquino

Affiliations Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
⨯
Néstor Kippes,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Mariana Malvicini,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Laura Alaniz,

Affiliations Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
⨯
Mariana Garcia,

Affiliations Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
⨯
Flavia Piccioni,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Esteban J. Fiore,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Juan Bayo,

Affiliation Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina
⨯
Ramón Bataller,

Affiliation Department of Medicine and Nutrition, University of North Carolina, Chapel Hill, North Carolina, United States of America
⨯
Elizabeth Guruceaga,

Affiliation Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona, España
⨯
Fernando Corrales,

Affiliation Centro de Investigación Médica Aplicada, Universidad de Navarra, Pamplona, España
⨯
Osvaldo Podhajcer,

Affiliations Gene Therapy Laboratory, Fundación Instituto Leloir, Buenos Aires, Argentina, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
⨯
Guillermo Mazzolini

* E-mail: gmazzoli@cas.austral.edu.ar

Affiliations Gene Therapy Laboratory, School of Medicine, Austral University. Derqui-Pilar, Buenos Aires, Argentina, CONICET (Consejo Nacional de Investigaciones Científicas y Técnicas), Buenos Aires, Argentina
⨯

Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice

Catalina Atorrasagasti,
Estanislao Peixoto,
Jorge B. Aquino,
Néstor Kippes,
Mariana Malvicini,
Laura Alaniz,
Mariana Garcia,
Flavia Piccioni,
Esteban J. Fiore,
Juan Bayo

Published: February 11, 2013
https://doi.org/10.1371/journal.pone.0054962

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Gene expression
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DNA repair
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