A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

Markus Thomas; Yvonne Kienast; Werner Scheuer; Monika Bähner; Klaus Kaluza; Christian Gassner; Frank Herting; Ulrich Brinkmann; Stefan Seeber; Anita Kavlie; Martin Welschof; Stefan Ries; K. Michael Weidner; Jörg T. Regula; Christian Klein

doi:10.1371/journal.pone.0054923

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Open Access

Peer-reviewed

Research Article

A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

Markus Thomas ,

* E-mail: markus.thomas@roche.com

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Yvonne Kienast,

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Werner Scheuer,

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Monika Bähner,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Klaus Kaluza,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Christian Gassner,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Frank Herting,

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Ulrich Brinkmann,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Stefan Seeber,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Anita Kavlie,

Affiliation Affitech Research AS, Oslo, Norway
⨯
Martin Welschof,

Current address: Opsona Therapeutics Ltd., Dublin, Ireland

Affiliation Affitech Research AS, Oslo, Norway
⨯
Stefan Ries,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
K. Michael Weidner,

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Jörg T. Regula,

Affiliation Biologics Research, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯
Christian Klein

Current address: Discovery Oncology, Pharma Research and Early Development, Roche Glycart AG, Schlieren, Switzerland

Affiliation Discovery Oncology, Pharma Research and Early Development, Roche Diagnostics GmbH, Penzberg, Germany
⨯

A Novel Angiopoietin-2 Selective Fully Human Antibody with Potent Anti-Tumoral and Anti-Angiogenic Efficacy and Superior Side Effect Profile Compared to Pan-Angiopoietin-1/-2 Inhibitors

Markus Thomas,
Yvonne Kienast,
Werner Scheuer,
Monika Bähner,
Klaus Kaluza,
Christian Gassner,
Frank Herting,
Ulrich Brinkmann,
Stefan Seeber,
Anita Kavlie

Published: February 6, 2013
https://doi.org/10.1371/journal.pone.0054923

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