Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Christopher Paustian; Patricia Taylor; Terrence Johnson; Min Xu; Nancy Ramirez; Kenneth S. Rosenthal; Suyu Shu; Peter A. Cohen; Brian J. Czerniecki; Gary K. Koski

doi:10.1371/journal.pone.0054804

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Peer-reviewed

Research Article

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Christopher Paustian,

Current address: Earle Chiles Research Institute, Providence Cancer Center, Portland, Oregon, United States of America

Affiliation Department of Biological Sciences, Biomedical Sciences Program, Kent State University, Kent, Ohio, United States of America
⨯
Patricia Taylor,

Affiliation Department of Integrative Medical Sciences, Northeastern Ohio Medical University, Rootstown, Ohio, United States of America
⨯
Terrence Johnson,

Affiliation Department of Biological Sciences, Biomedical Sciences Program, Kent State University, Kent, Ohio, United States of America
⨯
Min Xu,

Affiliation Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Nancy Ramirez,

Affiliation Department of Biological Sciences, Biomedical Sciences Program, Kent State University, Kent, Ohio, United States of America
⨯
Kenneth S. Rosenthal,

Affiliation Department of Integrative Medical Sciences, Northeastern Ohio Medical University, Rootstown, Ohio, United States of America
⨯
Suyu Shu,

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Peter A. Cohen,

Current address: Division of Hematology and Oncology, Mayo Clinic Arizona, Scottsdale, Arizona, United States of America

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Brian J. Czerniecki,

Affiliation Harrison Department of Surgical Research, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Gary K. Koski

* E-mail: dendritic_cell@hotmail.com

Affiliation Department of Biological Sciences, Biomedical Sciences Program, Kent State University, Kent, Ohio, United States of America
⨯

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Christopher Paustian,
Patricia Taylor,
Terrence Johnson,
Min Xu,
Nancy Ramirez,
Kenneth S. Rosenthal,
Suyu Shu,
Peter A. Cohen,
Brian J. Czerniecki,
Gary K. Koski

Published: January 31, 2013
https://doi.org/10.1371/journal.pone.0054804

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Monocytes
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Cytokines
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Immune receptor signaling
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T cells
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Secretion
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Toll-like receptors
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