The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α1-Antitrypsin

Open Access

Peer-reviewed

Research Article

The Roles of Helix I and Strand 5A in the Folding, Function and Misfolding of α₁-Antitrypsin

Anja S. Knaupp,

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
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Shani Keleher,

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
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Li Yang,

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
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Weiwen Dai,

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
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Stephen P. Bottomley ,

Contributed equally to this work with: Stephen P. Bottomley, Mary C. Pearce

* E-mail: steve.bottomley@monash.edu (SB); mary.pearce@monash.edu (MP)

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
⨯
Mary C. Pearce

Contributed equally to this work with: Stephen P. Bottomley, Mary C. Pearce

* E-mail: steve.bottomley@monash.edu (SB); mary.pearce@monash.edu (MP)

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
⨯

Polymerization
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Polymers
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Denaturation
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Transition state
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Thermodynamics
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Proteases
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Alanine
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Substitution mutation
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