Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

John R. Hawse; Malayannan Subramaniam; Muzaffer Cicek; Xianglin Wu; Anne Gingery; Sarah B. Grygo; Zhifu Sun; Kevin S. Pitel; Wilma L. Lingle; Matthew P. Goetz; James N. Ingle; Thomas C. Spelsberg

doi:10.1371/journal.pone.0054613

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Open Access

Peer-reviewed

Research Article

Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

John R. Hawse ,

* E-mail: hawse.john@mayo.edu

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Malayannan Subramaniam,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Muzaffer Cicek,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Xianglin Wu,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Anne Gingery,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Sarah B. Grygo,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Zhifu Sun,

Affiliation Bioinformatics Core, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Kevin S. Pitel,

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Wilma L. Lingle,

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Matthew P. Goetz,

Affiliation Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
James N. Ingle,

Affiliation Department of Oncology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Thomas C. Spelsberg

Affiliation Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens

John R. Hawse,
Malayannan Subramaniam,
Muzaffer Cicek,
Xianglin Wu,
Anne Gingery,
Sarah B. Grygo,
Zhifu Sun,
Kevin S. Pitel,
Wilma L. Lingle,
Matthew P. Goetz

Published: January 28, 2013
https://doi.org/10.1371/journal.pone.0054613

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