Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Andrea Cuconati; Courtney Mills; Cally Goddard; Xianchao Zhang; Wenquan Yu; Haitao Guo; Xiaodong Xu; Timothy M. Block

doi:10.1371/journal.pone.0054595

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Peer-reviewed

Research Article

Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Andrea Cuconati ,

* E-mail: acuconati.research@hepb.org (AC); Timothy.Block@drexelmed.edu(TB)

Affiliation Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America
⨯
Courtney Mills,

Affiliation Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America
⨯
Cally Goddard,

Affiliation Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America
⨯
Xianchao Zhang,

Affiliation Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
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Wenquan Yu,

Affiliations Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, People’s Republic of China
⨯
Haitao Guo,

Affiliation Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
⨯
Xiaodong Xu,

Affiliations Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America, Enantigen Therapeutics, Incorporated, Doylestown, Pennsylvania, United States of America
⨯
Timothy M. Block

* E-mail: acuconati.research@hepb.org (AC); Timothy.Block@drexelmed.edu(TB)

Affiliations Institute for Hepatitis and Virus Research, Hepatitis B Foundation, Doylestown, Pennsylvania, United States of America, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, Pennsylvania, United States of America
⨯

Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells

Andrea Cuconati,
Courtney Mills,
Cally Goddard,
Xianchao Zhang,
Wenquan Yu,
Haitao Guo,
Xiaodong Xu,
Timothy M. Block

Published: January 23, 2013
https://doi.org/10.1371/journal.pone.0054595

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Hepatocellular carcinoma
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Cancer treatment
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Apoptosis
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Cancers and neoplasms
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Cell staining
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Hepatocytes
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