SB225002 Promotes Mitotic Catastrophe in Chemo-Sensitive and -Resistant Ovarian Cancer Cells Independent of p53 Status In Vitro

Meirong Du; Qing Qiu; Andree Gruslin; John Gordon; Miao He; Chi Chung Chan; Dajin Li; Benjamin K. Tsang

doi:10.1371/journal.pone.0054572

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Open Access

Peer-reviewed

Research Article

SB225002 Promotes Mitotic Catastrophe in Chemo-Sensitive and -Resistant Ovarian Cancer Cells Independent of p53 Status In Vitro

Meirong Du,

Affiliations Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics & Gynecology, Institute of Biomedical Sciences, Fudan University Shanghai, Medical College, Shanghai, China, Departments of Cellular & Molecular Medicine and Obstetrics & Gynaecology, University of Ottawa, Ottawa, Canada, Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
⨯
Qing Qiu,

Affiliations Departments of Cellular & Molecular Medicine and Obstetrics & Gynaecology, University of Ottawa, Ottawa, Canada, Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
⨯
Andree Gruslin,

Affiliations Departments of Cellular & Molecular Medicine and Obstetrics & Gynaecology, University of Ottawa, Ottawa, Canada, Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
⨯
John Gordon,

Affiliation Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, Canada
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Miao He,

Affiliation WuXi AppTech Co., Ltd., Shanghai, China
⨯
Chi Chung Chan,

Affiliation WuXi AppTech Co., Ltd., Shanghai, China
⨯
Dajin Li ,

* E-mail: djli@shmu.edu.cn (DJL) (DL); btsang@ohri.ca (BKT) (BT)

Affiliations Laboratory for Reproductive Immunology, Hospital and Institute of Obstetrics & Gynecology, Institute of Biomedical Sciences, Fudan University Shanghai, Medical College, Shanghai, China, Department of Obstetrics & Gynecology, Hainan Medical College Affiliated Hospital, Haikou, China
⨯
Benjamin K. Tsang

* E-mail: djli@shmu.edu.cn (DJL) (DL); btsang@ohri.ca (BKT) (BT)

Affiliations Departments of Cellular & Molecular Medicine and Obstetrics & Gynaecology, University of Ottawa, Ottawa, Canada, Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada, Department of Obstetrics & Gynecology, Hainan Medical College Affiliated Hospital, Haikou, China, World Class University (WCU) Biomodulation Major, Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Republic of Korea
⨯

SB225002 Promotes Mitotic Catastrophe in Chemo-Sensitive and -Resistant Ovarian Cancer Cells Independent of p53 Status In Vitro

Meirong Du,
Qing Qiu,
Andree Gruslin,
John Gordon,
Miao He,
Chi Chung Chan,
Dajin Li,
Benjamin K. Tsang

Published: January 24, 2013
https://doi.org/10.1371/journal.pone.0054572

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