Glucuronidation by UGT1A1 Is the Dominant Pathway of the Metabolic Disposition of Belinostat in Liver Cancer Patients

• Ling-Zhi Wang,

  Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Jacqueline Ramírez,

  Affiliation Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America

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• Winnie Yeo,

  Affiliation Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China

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• Mei-Yi Michelle Chan,

  Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore

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• Win-Lwin Thuya,

  Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Jie-Ying Amelia Lau,

  Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Seow-Ching Wan,

  Affiliation Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore

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• Andrea Li-Ann Wong,

  Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

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• Ying-Kiat Zee,

  Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

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• Robert Lim,

  Affiliation Department of Hematology & Oncology, National University Health System, Singapore, Singapore

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• Soo-Chin Lee,

  Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Hematology & Oncology, National University Health System, Singapore, Singapore

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• Paul C. Ho,

  Affiliation Department of Pharmacy, National University of Singapore, Singapore, Singapore

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• How-Sung Lee,

  Affiliation Department of Pharmacology, National University of Singapore, Singapore, Singapore

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• Anthony Chan,

  Affiliation Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, China

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• Sherry Ansher,

  Affiliation Cancer Therapy Evaluation Program, Bethesda, Maryland, United States of America

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• Mark J. Ratain,

  Affiliations Department of Medicine, The University of Chicago, Chicago, Illinois, United States of America, Committee on Clinical Pharmacology and Pharmacogenomics, The University of Chicago, Chicago, Illinois, United States of America, Comprehensive Cancer Center, The University of Chicago, Chicago, Illinois, United States of America

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•  [ ... ],
• Boon-Cher Goh

  * E-mail: phcgbc@nus.edu.sg

  Affiliations Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore, Department of Pharmacology, National University of Singapore, Singapore, Singapore, Department of Hematology & Oncology, National University Health System, Singapore, Singapore

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