Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

Yi Zhu; Karla M. P. Pires; Kevin J. Whitehead; Curtis D. Olsen; Benjamin Wayment; Yi Cheng Zhang; Heiko Bugger; Olesya Ilkun; Sheldon E. Litwin; George Thomas; Sara C. Kozma; E. Dale Abel

doi:10.1371/journal.pone.0054221

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Open Access

Peer-reviewed

Research Article

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

Yi Zhu,

Affiliations Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America, Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Karla M. P. Pires,

Affiliations Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America, Biomedical Center, Institute of Biology, Laboratory of Morphometry and Cardiovascular Morphology, State University of Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Kevin J. Whitehead,

Affiliation Division of Cardiology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Curtis D. Olsen,

Affiliation Division of Cardiology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Benjamin Wayment,

Affiliation Division of Cardiology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Yi Cheng Zhang,

Affiliation Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Heiko Bugger,

Current address: Division of Cardiology, University of Freiburg, Freiburg im Breisgau, Germany

Affiliation Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Olesya Ilkun,

Affiliation Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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Sheldon E. Litwin,

Current address: Division of Cardiology, Georgia Health Sciences University, Augusta, Georgia, United States of America

Affiliation Division of Cardiology, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
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George Thomas,

Affiliation Division of Hematology-Oncology, Department of Internal Medicine, Metabolic Diseases Institute, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
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Sara C. Kozma,

Affiliation Division of Hematology-Oncology, Department of Internal Medicine, Metabolic Diseases Institute, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
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E. Dale Abel

* E-mail: dale.abel@hmbg.utah.edu

Affiliations Division of Endocrinology, Metabolism, and Diabetes and Program in Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America, Department of Biochemistry, School of Medicine, University of Utah, Salt Lake City, Utah, United States of America
⨯

Mechanistic Target of Rapamycin (Mtor) Is Essential for Murine Embryonic Heart Development and Growth

Yi Zhu,
Karla M. P. Pires,
Kevin J. Whitehead,
Curtis D. Olsen,
Benjamin Wayment,
Yi Cheng Zhang,
Heiko Bugger,
Olesya Ilkun,
Sheldon E. Litwin,
George Thomas

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0054221

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