Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature

Martin P. Barr; Steven G. Gray; Andreas C. Hoffmann; Ralf A. Hilger; Juergen Thomale; John D. O’Flaherty; Dean A. Fennell; Derek Richard; John J. O’Leary; Kenneth J. O’Byrne

doi:10.1371/journal.pone.0054193

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Open Access

Peer-reviewed

Research Article

Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature

Martin P. Barr ,

* E-mail: mbarr@stjames.ie

Affiliation Thoracic Oncology, Institute of Molecular Medicine, Trinity Centre for Health Sciences St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
⨯
Steven G. Gray,

Affiliation Thoracic Oncology, Institute of Molecular Medicine, Trinity Centre for Health Sciences St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
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Andreas C. Hoffmann,

Affiliation Molecular Oncology Risk-Profile Evaluation (M.O.R.E.), Department of Medical Oncology, West German Cancer Centre, University Hospital Essen, Essen, Germany
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Ralf A. Hilger,

Affiliation Molecular Oncology Risk-Profile Evaluation (M.O.R.E.), Department of Medical Oncology, West German Cancer Centre, University Hospital Essen, Essen, Germany
⨯
Juergen Thomale,

Affiliation Department of Cell Biology (Cancer Research), University Duisburg-Essen, Essen, Germany
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John D. O’Flaherty,

Affiliation Thoracic Oncology, Institute of Molecular Medicine, Trinity Centre for Health Sciences St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
⨯
Dean A. Fennell,

Affiliation Thoracic Medical Oncology, University of Leicester & Leicester University Hospitals, Leicester, United Kingdom
⨯
Derek Richard,

Affiliation Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, Australia
⨯
John J. O’Leary,

Affiliation Department of Histopathology, St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
⨯
Kenneth J. O’Byrne

Affiliation Thoracic Oncology, Institute of Molecular Medicine, Trinity Centre for Health Sciences St. James’s Hospital & Trinity College Dublin, Dublin, Ireland
⨯

Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature

Martin P. Barr,
Steven G. Gray,
Andreas C. Hoffmann,
Ralf A. Hilger,
Juergen Thomale,
John D. O’Flaherty,
Dean A. Fennell,
Derek Richard,
John J. O’Leary,
Kenneth J. O’Byrne

Published: January 17, 2013
https://doi.org/10.1371/journal.pone.0054193

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Non-small cell lung cancer
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