A Novel and Selective Poly (ADP-Ribose) Polymerase Inhibitor Ameliorates Chemotherapy-Induced Painful Neuropathy

Lauren E. Ta; James D. Schmelzer; Allan J. Bieber; Charles L. Loprinzi; Gary C. Sieck; Jill D. Brederson; Philip A. Low; Anthony J. Windebank

doi:10.1371/journal.pone.0054161

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Peer-reviewed

Research Article

A Novel and Selective Poly (ADP-Ribose) Polymerase Inhibitor Ameliorates Chemotherapy-Induced Painful Neuropathy

Lauren E. Ta ,

* E-mail: ta.lauren@mayo.edu

Affiliations Department of Neurology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Department of Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Program in Molecular Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
⨯
James D. Schmelzer,

Affiliation Department of Neurology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
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Allan J. Bieber,

Affiliations Department of Neurology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Department of Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Program in Molecular Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
⨯
Charles L. Loprinzi,

Affiliation Division of Medical Oncology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
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Gary C. Sieck,

Affiliation Department of Physiology and Biomedical Engineering, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
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Jill D. Brederson,

Affiliation Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, United States of America
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Philip A. Low,

Affiliation Department of Neurology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
⨯
Anthony J. Windebank

Affiliations Department of Neurology, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Department of Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America, Program in Molecular Neuroscience, Mayo Clinic, College of Medicine, Rochester, Minnesota, United States of America
⨯

A Novel and Selective Poly (ADP-Ribose) Polymerase Inhibitor Ameliorates Chemotherapy-Induced Painful Neuropathy

Lauren E. Ta,
James D. Schmelzer,
Allan J. Bieber,
Charles L. Loprinzi,
Gary C. Sieck,
Jill D. Brederson,
Philip A. Low,
Anthony J. Windebank

Published: January 10, 2013
https://doi.org/10.1371/journal.pone.0054161

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