Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer

Jae Young So; Amanda K. Smolarek; David M. Salerno; Hubert Maehr; Milan Uskokovic; Fang Liu; Nanjoo Suh

doi:10.1371/journal.pone.0054020

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Peer-reviewed

Research Article

Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer

Jae Young So,

Affiliations Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America, Graduate Program in Cellular and Molecular Pharmacology, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
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Amanda K. Smolarek,

Affiliation Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
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David M. Salerno,

Affiliation Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
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Hubert Maehr,

Affiliation Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
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Milan Uskokovic,

Affiliation Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
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Fang Liu,

Affiliations Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America, Center for Advanced Biotechnology and Medicine, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America, The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
⨯
Nanjoo Suh

* E-mail: nsuh@pharmacy.rutgers.edu

Affiliations Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America, The Cancer Institute of New Jersey, New Brunswick, New Jersey, United States of America
⨯

Targeting CD44-STAT3 Signaling by Gemini Vitamin D Analog Leads to Inhibition of Invasion in Basal-Like Breast Cancer

Jae Young So,
Amanda K. Smolarek,
David M. Salerno,
Hubert Maehr,
Milan Uskokovic,
Fang Liu,
Nanjoo Suh

Published: January 11, 2013
https://doi.org/10.1371/journal.pone.0054020

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Breast cancer
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STAT signaling
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Signal inhibition
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Gene expression
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Immunoprecipitation
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Vitamin D
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Cancers and neoplasms
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Invasive tumors
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