Liposomal Targeting of Prednisolone Phosphate to Synovial Lining Macrophages during Experimental Arthritis Inhibits M1 Activation but Does Not Favor M2 Differentiation

Open Access

Peer-reviewed

Research Article

Wouter Hofkens,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
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Rik Schelbergen,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
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Gert Storm,

Affiliation Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
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Wim B. van den Berg,

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
⨯
Peter L. van Lent

* E-mail: p.vanlent@reuma.umcn.nl

Affiliation Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
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Macrophages
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Knee joints
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Arthritis
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Liposomes
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Inflammation
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Intravenous injections
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Cytokines
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Gene expression
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