STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G2 Arrest in the Absence of DNA Damage

Sun-Ok Kim; Krisada Sakchaisri; Thimmegowda N. R.; Nak Kyun Soung; Jae-Hyuk Jang; Young Sang Kim; Kyung Sang Lee; Yong Tae Kwon; Yukihiro Asami; Jong Seog Ahn; Raymond Leo Erikson; Bo Yeon Kim

doi:10.1371/journal.pone.0053908

Loading metrics

Open Access

Peer-reviewed

Research Article

STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G₂ Arrest in the Absence of DNA Damage

Sun-Ok Kim ,

Contributed equally to this work with: Sun-Ok Kim, Krisada Sakchaisri

Affiliations Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea, Department of Biochemistry, College of Natural Sciences, ChungNam National University, Yuseonggu, Daejeon, Korea
⨯
Krisada Sakchaisri ,

Contributed equally to this work with: Sun-Ok Kim, Krisada Sakchaisri

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯
Thimmegowda N. R.,

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯
Nak Kyun Soung,

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯
Jae-Hyuk Jang,

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯
Young Sang Kim,

Affiliation Department of Biochemistry, College of Natural Sciences, ChungNam National University, Yuseonggu, Daejeon, Korea
⨯
Kyung Sang Lee,

Affiliation Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Yong Tae Kwon,

Affiliations World Class University (WCU), Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea, Center for Pharmacogenetics and Department of Pharmaceutical Sciences, School of Pharmacy, Universigy of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Yukihiro Asami,

Affiliation Chemical Biology Department, RIKEN Advanced Science Institute, Wako-shi, Saitama, Japan
⨯
Jong Seog Ahn ,

* E-mail: bykim@kribb.re.kr (BYK); jsahn@kribb.re.kr (JSA)

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯
Raymond Leo Erikson,

Affiliation Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Bo Yeon Kim

* E-mail: bykim@kribb.re.kr (BYK); jsahn@kribb.re.kr (JSA)

Affiliation Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Cheongwon, Korea
⨯

STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G₂ Arrest in the Absence of DNA Damage

Sun-Ok Kim,
Krisada Sakchaisri,
Thimmegowda N. R.,
Nak Kyun Soung,
Jae-Hyuk Jang,
Young Sang Kim,
Kyung Sang Lee,
Yong Tae Kwon,
Yukihiro Asami,
Jong Seog Ahn

Published: January 22, 2013
https://doi.org/10.1371/journal.pone.0053908

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cyclins
Is the Subject Area "Cyclins" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Hepatocellular carcinoma
Is the Subject Area "Hepatocellular carcinoma" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.