Standardized Environmental Enrichment Supports Enhanced Brain Plasticity in Healthy Rats and Prevents Cognitive Impairment in Epileptic Rats

Raafat P. Fares; Amor Belmeguenai; Pascal E. Sanchez; Hayet Y. Kouchi; Jacques Bodennec; Anne Morales; Béatrice Georges; Chantal Bonnet; Sandrine Bouvard; Robert S. Sloviter; Laurent Bezin

doi:10.1371/journal.pone.0053888

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Research Article

Standardized Environmental Enrichment Supports Enhanced Brain Plasticity in Healthy Rats and Prevents Cognitive Impairment in Epileptic Rats

Raafat P. Fares ,

Contributed equally to this work with: Raafat P. Fares, Amor Belmeguenai, Pascal E. Sanchez

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France, IRBA, Institut de Recherche Biomédicale des Armées, Brétigny-sur-Orge, France
⨯
Amor Belmeguenai ,

Contributed equally to this work with: Raafat P. Fares, Amor Belmeguenai, Pascal E. Sanchez

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯
Pascal E. Sanchez ,

Contributed equally to this work with: Raafat P. Fares, Amor Belmeguenai, Pascal E. Sanchez

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
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Hayet Y. Kouchi,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯
Jacques Bodennec,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯
Anne Morales,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
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Béatrice Georges,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯
Chantal Bonnet,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
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Sandrine Bouvard,

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯
Robert S. Sloviter,

Affiliation Department of Neurobiology, Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia, United States of America
⨯
Laurent Bezin

* E-mail: laurent.bezin@univ-lyon1.fr

Affiliations Université de Lyon, Lyon, France, Université Lyon 1, Villeurbanne, France, Inserm, Institut National de la Santé et de la Recherche Médicale, U1028, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, CNRS, Centre National de la Recherche Scientifique, UMR5292, Lyon Neuroscience Research Center, Tiger Team, Lyon, France, IDÉE, Institut Des ÉpilepsiEs, Lyon, France
⨯

Standardized Environmental Enrichment Supports Enhanced Brain Plasticity in Healthy Rats and Prevents Cognitive Impairment in Epileptic Rats

Raafat P. Fares,
Amor Belmeguenai,
Pascal E. Sanchez,
Hayet Y. Kouchi,
Jacques Bodennec,
Anne Morales,
Béatrice Georges,
Chantal Bonnet,
Sandrine Bouvard,
Robert S. Sloviter

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0053888

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