GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo

Okjae Lim; Yuna Lee; Hyejin Chung; Jung Hyun Her; Sang Mi Kang; Mi-young Jung; Bokyung Min; Hyejin Shin; Tae Min Kim; Dae Seog Heo; Yu Kyeong Hwang; Eui-Cheol Shin

doi:10.1371/journal.pone.0053611

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Open Access

Peer-reviewed

Research Article

GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo

Okjae Lim,

Affiliations BioMedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, Republic of Korea, Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea, Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea
⨯
Yuna Lee,

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Hyejin Chung,

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Jung Hyun Her,

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Sang Mi Kang,

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Mi-young Jung,

Affiliation Cell Therapy Division, Green Cross LabCell Corp., Yongin, Gyeonggi-do, Republic of Korea
⨯
Bokyung Min,

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Hyejin Shin,

Affiliation Cell Therapy Division, Green Cross LabCell Corp., Yongin, Gyeonggi-do, Republic of Korea
⨯
Tae Min Kim,

Affiliation Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
⨯
Dae Seog Heo,

Affiliation Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea
⨯
Yu Kyeong Hwang ,

* E-mail: ykhwang@mogam.re.kr (YKH); ecshin@kaist.ac.kr (ECS)

Affiliation Cell Therapy Team, Mogam Biotechnology Research Institute, Yongin, Gyeonggi-do, Republic of Korea
⨯
Eui-Cheol Shin

* E-mail: ykhwang@mogam.re.kr (YKH); ecshin@kaist.ac.kr (ECS)

Affiliations BioMedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon, Republic of Korea, Laboratory of Immunology and Infectious Diseases, Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea
⨯

GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo

Okjae Lim,
Yuna Lee,
Hyejin Chung,
Jung Hyun Her,
Sang Mi Kang,
Mi-young Jung,
Bokyung Min,
Hyejin Shin,
Tae Min Kim,
Dae Seog Heo

Published: January 11, 2013
https://doi.org/10.1371/journal.pone.0053611

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