Disruption of Smad7 Promotes ANG II-Mediated Renal Inflammation and Fibrosis via Sp1-TGF-β/Smad3-NF.κB-Dependent Mechanisms in Mice

• Guan-Xian Liu ,

  Contributed equally to this work with: Guan-Xian Liu, You-Qi Li

  * E-mail: hylan@cuhk.edu.hk (HYL); liyouqi0330@163.com (GXL)

  Affiliation Department of Nephrology, Central Municipal Hospital of Huizhou, Guangdong, China

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• You-Qi Li ,

  Contributed equally to this work with: Guan-Xian Liu, You-Qi Li

  Affiliation Department of Nephrology, Central Municipal Hospital of Huizhou, Guangdong, China

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• Xiao R. Huang,

  Affiliations CUHK Research Institute, Shenzhen, Guangdong, China, Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

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• Lihua Wei,

  Affiliation CUHK Research Institute, Shenzhen, Guangdong, China

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• Hai-Yong Chen,

  Affiliation CUHK Research Institute, Shenzhen, Guangdong, China

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• Yong-Jun Shi,

  Affiliation Department of Nephrology, Central Municipal Hospital of Huizhou, Guangdong, China

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• Rainer L. Heuchel,

  Affiliation Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

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• Hui Y. Lan

  * E-mail: hylan@cuhk.edu.hk (HYL); liyouqi0330@163.com (GXL)

  Affiliations CUHK Research Institute, Shenzhen, Guangdong, China, Department of Medicine and Therapeutics, and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

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