Co-Culture of Hematopoietic Stem/Progenitor Cells with Human Osteblasts Favours Mono/Macrophage Differentiation at the Expense of the Erythroid Lineage

Simona Salati; Gina Lisignoli; Cristina Manferdini; Valentina Pennucci; Roberta Zini; Elisa Bianchi; Ruggiero Norfo; Andrea Facchini; Sergio Ferrari; Rossella Manfredini

doi:10.1371/journal.pone.0053496

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Peer-reviewed

Research Article

Co-Culture of Hematopoietic Stem/Progenitor Cells with Human Osteblasts Favours Mono/Macrophage Differentiation at the Expense of the Erythroid Lineage

Simona Salati,

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯
Gina Lisignoli,

Affiliations SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯
Cristina Manferdini,

Affiliations SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy
⨯
Valentina Pennucci,

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯
Roberta Zini,

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯
Elisa Bianchi,

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯
Ruggiero Norfo,

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯
Andrea Facchini,

Affiliations SC Laboratorio di Immunoreumatologia e Rigenerazione Tissutale, Istituto Ortopedico Rizzoli, Bologna, Italy, Laboratorio RAMSES, Istituto Ortopedico Rizzoli, Bologna, Italy, Dipartimento di Scienze Mediche e Chirurgiche, University of Bologna, Bologna, Italy
⨯
Sergio Ferrari,

Affiliation Life Sciences Department, University of Modena and Reggio Emilia, Modena, Italy
⨯
Rossella Manfredini

* E-mail: rossella.manfredini@unimore.it

Affiliation Centre for Regenerative Medicine “Stefano Ferrari”, University of Modena and Reggio Emilia, Modena, Italy
⨯

Co-Culture of Hematopoietic Stem/Progenitor Cells with Human Osteblasts Favours Mono/Macrophage Differentiation at the Expense of the Erythroid Lineage

Simona Salati,
Gina Lisignoli,
Cristina Manferdini,
Valentina Pennucci,
Roberta Zini,
Elisa Bianchi,
Ruggiero Norfo,
Andrea Facchini,
Sergio Ferrari,
Rossella Manfredini

Published: January 22, 2013
https://doi.org/10.1371/journal.pone.0053496

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Cell differentiation
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