Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

Julia S. Gelman; Juan Sironi; Iryna Berezniuk; Sayani Dasgupta; Leandro M. Castro; Fabio C. Gozzo; Emer S. Ferro; Lloyd D. Fricker

doi:10.1371/journal.pone.0053263

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Open Access

Peer-reviewed

Research Article

Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

Julia S. Gelman ,

Contributed equally to this work with: Julia S. Gelman, Juan Sironi

Affiliations Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Juan Sironi ,

Contributed equally to this work with: Julia S. Gelman, Juan Sironi

Affiliation Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Iryna Berezniuk,

Affiliations Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Sayani Dasgupta,

Affiliation Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America
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Leandro M. Castro,

Affiliation Department of Cell Biology and Development, University of São Paulo, São Paulo, Brazil
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Fabio C. Gozzo,

Affiliation Chemistry Institute, State University of Campinas, São Paulo, Brazil
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Emer S. Ferro,

Affiliation Department of Cell Biology and Development, University of São Paulo, São Paulo, Brazil
⨯
Lloyd D. Fricker

* E-mail: Lloyd.fricker@einstein.yu.edu

Affiliations Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

Alterations of the Intracellular Peptidome in Response to the Proteasome Inhibitor Bortezomib

Julia S. Gelman,
Juan Sironi,
Iryna Berezniuk,
Sayani Dasgupta,
Leandro M. Castro,
Fabio C. Gozzo,
Emer S. Ferro,
Lloyd D. Fricker

Published: January 7, 2013
https://doi.org/10.1371/journal.pone.0053263

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Proteasomes
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Autophagic cell death
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Mitochondria
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Proteases
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Peptide mapping
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Proteasome inhibitors
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