The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence and Apoptosis in Association with Accumulation of DNA Damage Markers

Valeria V. Costantino; Sabrina F. Mansilla; Juliana Speroni; Celina Amaya; Darío Cuello-Carrión; Daniel R. Ciocca; Horacio A. Priestap; Manuel A. Barbieri; Vanesa Gottifredi; Luis A. Lopez

doi:10.1371/journal.pone.0053168

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Peer-reviewed

Research Article

The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence and Apoptosis in Association with Accumulation of DNA Damage Markers

Valeria V. Costantino,

Affiliation Laboratory of Cell Cycle and Cytoskeleton, Instituto de Histología y Embriología Dr. M. H. Burgos (IHEM), Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
⨯
Sabrina F. Mansilla,

Affiliation Cell Cycle and Genomic Stability Laboratory, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina
⨯
Juliana Speroni,

Affiliation Cell Cycle and Genomic Stability Laboratory, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina
⨯
Celina Amaya,

Affiliation Laboratory of Cell Cycle and Cytoskeleton, Instituto de Histología y Embriología Dr. M. H. Burgos (IHEM), Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
⨯
Darío Cuello-Carrión,

Affiliation Instituto de Medicina y Biología Experimental de Cuyo IMBECU-CONICET, Mendoza, Argentina
⨯
Daniel R. Ciocca,

Affiliation Instituto de Medicina y Biología Experimental de Cuyo IMBECU-CONICET, Mendoza, Argentina
⨯
Horacio A. Priestap,

Affiliation Department of Biological Sciences, Florida International University, Miami, Florida, United States of America
⨯
Manuel A. Barbieri,

Affiliations Department of Biological Sciences, Florida International University, Miami, Florida, United States of America, Fairchild Tropical Botanic Garden, Coral Gables, Florida, United States of America
⨯
Vanesa Gottifredi ,

* E-mail: vgottifredi@leloir.org.ar (VG); llopez@fcm.uncu.edu.ar (LAL)

Affiliation Cell Cycle and Genomic Stability Laboratory, Fundación Instituto Leloir-CONICET, Buenos Aires, Argentina
⨯
Luis A. Lopez

* E-mail: vgottifredi@leloir.org.ar (VG); llopez@fcm.uncu.edu.ar (LAL)

Affiliation Laboratory of Cell Cycle and Cytoskeleton, Instituto de Histología y Embriología Dr. M. H. Burgos (IHEM), Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Mendoza, Argentina
⨯

The Sesquiterpene Lactone Dehydroleucodine Triggers Senescence and Apoptosis in Association with Accumulation of DNA Damage Markers

Valeria V. Costantino,
Sabrina F. Mansilla,
Juliana Speroni,
Celina Amaya,
Darío Cuello-Carrión,
Daniel R. Ciocca,
Horacio A. Priestap,
Manuel A. Barbieri,
Vanesa Gottifredi,
Luis A. Lopez

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0053168

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