Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1α Pathway

Wei-Bin Cai; Yang Zhang; Rui Cheng; Zheng Wang; Shu-Huan Fang; Zu-Min Xu; Xia Yang; Zhong-Han Yang; Jian-Xing Ma; Chun-Kui Shao; Guo-Quan Gao

doi:10.1371/journal.pone.0053152

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Open Access

Peer-reviewed

Research Article

Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1α Pathway

Wei-Bin Cai ,

Contributed equally to this work with: Wei-Bin Cai, Yang Zhang

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Yang Zhang ,

Contributed equally to this work with: Wei-Bin Cai, Yang Zhang

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Rui Cheng,

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Zheng Wang,

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Shu-Huan Fang,

Affiliations Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, DME Center, Clinical Pharmacology Institute, Guangzhou University of Chinese Medicine, Guangzhou, China
⨯
Zu-Min Xu,

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Xia Yang,

Affiliations Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, Key Laboratory of Functional Molecules from Marine Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou, China
⨯
Zhong-Han Yang,

Affiliation Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
⨯
Jian-Xing Ma,

Affiliation Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America
⨯
Chun-Kui Shao ,

* E-mail: gaogq@mail.sysu.edu.cn (GQG); chunkuishao2011@163.com (CKS)

Affiliation Department of Pathology, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Guo-Quan Gao

* E-mail: gaogq@mail.sysu.edu.cn (GQG); chunkuishao2011@163.com (CKS)

Affiliations Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China, China Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China
⨯

Dual Inhibition of Plasminogen Kringle 5 on Angiogenesis and Chemotaxis Suppresses Tumor Metastasis by Targeting HIF-1α Pathway

Wei-Bin Cai,
Yang Zhang,
Rui Cheng,
Zheng Wang,
Shu-Huan Fang,
Zu-Min Xu,
Xia Yang,
Zhong-Han Yang,
Jian-Xing Ma,
Chun-Kui Shao

Published: December 31, 2012
https://doi.org/10.1371/journal.pone.0053152

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