Positive Selection in the Chromosome 16 VKORC1 Genomic Region Has Contributed to the Variability of Anticoagulant Response in Humans

• Blandine Patillon ,

  Contributed equally to this work with: Blandine Patillon, Pierre Luisi, Emmanuelle Génin, Audrey Sabbagh

  * E-mail: blandine.patillon@inserm.fr

  Affiliations Inserm UMRS-946, Genetic Variability and Human Diseases, Institut Universitaire d’Hématologie, Université Paris Diderot, Paris, France, Université Paris Sud, Kremlin-Bicêtre, France

  ⨯
• Pierre Luisi ,

  Contributed equally to this work with: Blandine Patillon, Pierre Luisi, Emmanuelle Génin, Audrey Sabbagh

  Affiliation Institute of Evolutionary Biology, CEXS-UPF-PRBB, Catalonia, Barcelona, Spain

  ⨯
• Hélène Blanché,

  Affiliation Fondation Jean-Dausset-CEPH, Paris, France

  ⨯
• Etienne Patin,

  Affiliation Human Evolutionary Genetics, CNRS URA3012, Institut Pasteur, Paris, France

  ⨯
• Howard M. Cann,

  Affiliation Fondation Jean-Dausset-CEPH, Paris, France

  ⨯
• Emmanuelle Génin ,

  Contributed equally to this work with: Blandine Patillon, Pierre Luisi, Emmanuelle Génin, Audrey Sabbagh

  Affiliation Inserm UMRS-946, Genetic Variability and Human Diseases, Institut Universitaire d’Hématologie, Université Paris Diderot, Paris, France

  ⨯
• Audrey Sabbagh

  Contributed equally to this work with: Blandine Patillon, Pierre Luisi, Emmanuelle Génin, Audrey Sabbagh

  Affiliation UMR IRD 216, Université Paris Descartes, Paris, France

  ⨯