Lack of Avidity Maturation of Merozoite Antigen-Specific Antibodies with Increasing Exposure to Plasmodium falciparum amongst Children and Adults Exposed to Endemic Malaria in Kenya

Frances Ibison; Ally Olotu; Daniel M. Muema; Jedida Mwacharo; Eric Ohuma; Domtila Kimani; Kevin Marsh; Philip Bejon; Francis M. Ndungu

doi:10.1371/journal.pone.0052939

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Peer-reviewed

Research Article

Lack of Avidity Maturation of Merozoite Antigen-Specific Antibodies with Increasing Exposure to Plasmodium falciparum amongst Children and Adults Exposed to Endemic Malaria in Kenya

Frances Ibison,

Affiliations Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya, University of Birmingham Medical School, Edgbaston, Birmingham, United Kingdom
⨯
Ally Olotu,

Affiliation Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
⨯
Daniel M. Muema,

Affiliation Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
⨯
Jedida Mwacharo,

Affiliation Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
⨯
Eric Ohuma,

Affiliation Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
⨯
Domtila Kimani,

Affiliation Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya
⨯
Kevin Marsh,

Affiliations Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Philip Bejon,

Affiliations Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Francis M. Ndungu

* E-mail: FNdungu@kemri-wellcome.org

Affiliations Kenya Medical Research Institute, Centre for Geographical Medicine Research (Coast), Kilifi, Kenya, University of Oxford, Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯

Lack of Avidity Maturation of Merozoite Antigen-Specific Antibodies with Increasing Exposure to Plasmodium falciparum amongst Children and Adults Exposed to Endemic Malaria in Kenya

Frances Ibison,
Ally Olotu,
Daniel M. Muema,
Jedida Mwacharo,
Eric Ohuma,
Domtila Kimani,
Kevin Marsh,
Philip Bejon,
Francis M. Ndungu

Published: December 26, 2012
https://doi.org/10.1371/journal.pone.0052939

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Antibodies
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Immunohistochemistry techniques
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Children
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Merozoites
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