Different Patterns of White Matter Degeneration Using Multiple Diffusion Indices and Volumetric Data in Mild Cognitive Impairment and Alzheimer Patients

Gilberto Sousa Alves; Laurence O’Dwyer; Alina Jurcoane; Viola Oertel-Knöchel; Christian Knöchel; David Prvulovic; Felipe Sudo; Carlos Eduardo Alves; Letice Valente; Denise Moreira; Fabian Fuβer; Tarik Karakaya; Johannes Pantel; Eliasz Engelhardt; Jerson Laks

doi:10.1371/journal.pone.0052859

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Open Access

Peer-reviewed

Research Article

Different Patterns of White Matter Degeneration Using Multiple Diffusion Indices and Volumetric Data in Mild Cognitive Impairment and Alzheimer Patients

Gilberto Sousa Alves ,

* E-mail: gsalves123@hotmail.com

Affiliations Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Laurence O’Dwyer,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Alina Jurcoane,

Affiliation Institute of General Practice, Geriatric Medicine, Goethe-University, Frankfurt am Main, Germany
⨯
Viola Oertel-Knöchel,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Christian Knöchel,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
David Prvulovic,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Felipe Sudo,

Affiliation Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
⨯
Carlos Eduardo Alves,

Affiliation Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
⨯
Letice Valente,

Affiliation Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
⨯
Denise Moreira,

Affiliations Radiology Service – Instituto de Neurologia Deolindo Couto, Universidade Federal do Rio de Janeiro, Procardíaco Hospital, Rio de Janeiro, Brazil, Institute for Neuroradiology, Goethe-University, Frankfurt am Main, Germany
⨯
Fabian Fuβer,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Tarik Karakaya,

Affiliation Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt am Main, Germany
⨯
Johannes Pantel,

Affiliation Institute of General Practice, Geriatric Medicine, Goethe-University, Frankfurt am Main, Germany
⨯
Eliasz Engelhardt,

Affiliations Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil, Cognitive and Behavior Neurology Unit – Institute of Neurology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
⨯
Jerson Laks

Affiliation Alzheimer’s Disease Center – Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
⨯

Different Patterns of White Matter Degeneration Using Multiple Diffusion Indices and Volumetric Data in Mild Cognitive Impairment and Alzheimer Patients

Gilberto Sousa Alves,
Laurence O’Dwyer,
Alina Jurcoane,
Viola Oertel-Knöchel,
Christian Knöchel,
David Prvulovic,
Felipe Sudo,
Carlos Eduardo Alves,
Letice Valente,
Denise Moreira

Published: December 31, 2012
https://doi.org/10.1371/journal.pone.0052859

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