Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis

Sofia Theodoropoulou; Katarzyna Brodowska; Maki Kayama; Yuki Morizane; Joan W. Miller; Evangelos S. Gragoudas; Demetrios G. Vavvas

doi:10.1371/journal.pone.0052852

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Research Article

Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis

Sofia Theodoropoulou,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Katarzyna Brodowska,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Maki Kayama,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yuki Morizane,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joan W. Miller,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Evangelos S. Gragoudas,

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Demetrios G. Vavvas

* E-mail: vavvas@meei.harvard.edu

Affiliation Angiogenesis Laboratory, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Retina Service, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Aminoimidazole Carboxamide Ribonucleotide (AICAR) Inhibits the Growth of Retinoblastoma In Vivo by Decreasing Angiogenesis and Inducing Apoptosis

Sofia Theodoropoulou,
Katarzyna Brodowska,
Maki Kayama,
Yuki Morizane,
Joan W. Miller,
Evangelos S. Gragoudas,
Demetrios G. Vavvas

Published: January 3, 2013
https://doi.org/10.1371/journal.pone.0052852

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Cancers and neoplasms
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Retinoblastoma
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