Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells

Anna G. Drannik; Kakon Nag; Xiao-Dan Yao; Bethany M. Henrick; T. Blake Ball; Francis A. Plummer; Charles Wachihi; Joshua Kimani; Kenneth L. Rosenthal

doi:10.1371/journal.pone.0052738

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Peer-reviewed

Research Article

Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells

Anna G. Drannik ,

Contributed equally to this work with: Anna G. Drannik, Kakon Nag

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
Kakon Nag ,

Contributed equally to this work with: Anna G. Drannik, Kakon Nag

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
Xiao-Dan Yao,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
Bethany M. Henrick,

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯
T. Blake Ball,

Affiliation Department of Medical Microbiology, University of Manitoba and Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Francis A. Plummer,

Affiliation Department of Medical Microbiology, University of Manitoba and Public Health Agency of Canada, Winnipeg, Manitoba, Canada
⨯
Charles Wachihi,

Affiliation Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
⨯
Joshua Kimani,

Affiliation Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
⨯
Kenneth L. Rosenthal

* E-mail: rosenthl@mcmaster.ca

Affiliation Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
⨯

Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells

Anna G. Drannik,
Kakon Nag,
Xiao-Dan Yao,
Bethany M. Henrick,
T. Blake Ball,
Francis A. Plummer,
Charles Wachihi,
Joshua Kimani,
Kenneth L. Rosenthal

Published: December 27, 2012
https://doi.org/10.1371/journal.pone.0052738

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