Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

Kristin M. Narayan; Nitish Agrawal; Sean X. Du; Janelle E. Muranaka; Katherine Bauer; Daniel P. Leaman; Pham Phung; Kay Limoli; Helen Chen; Rebecca I. Boenig; Terri Wrin; Michael B. Zwick; Robert G. Whalen

doi:10.1371/journal.pone.0052732

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Open Access

Peer-reviewed

Research Article

Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

Kristin M. Narayan,

Affiliations Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America, Altravax, Inc., Sunnyvale, California, United States of America
⨯
Nitish Agrawal,

Affiliation Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Sean X. Du,

Current address: Simcere Pharmaceutical Group, Institute of Vaccine Research, Nanjing, People's Republic of China

Affiliations Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America, Altravax, Inc., Sunnyvale, California, United States of America
⨯
Janelle E. Muranaka,

Affiliations Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America, Altravax, Inc., Sunnyvale, California, United States of America
⨯
Katherine Bauer,

Affiliation Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Daniel P. Leaman,

Affiliation Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Pham Phung,

Affiliation Monogram Biosciences, Inc., San Francisco, California, United States of America
⨯
Kay Limoli,

Affiliation Monogram Biosciences, Inc., San Francisco, California, United States of America
⨯
Helen Chen,

Affiliation Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America
⨯
Rebecca I. Boenig,

Affiliations Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America, Altravax, Inc., Sunnyvale, California, United States of America
⨯
Terri Wrin,

Affiliation Monogram Biosciences, Inc., San Francisco, California, United States of America
⨯
Michael B. Zwick ,

* E-mail: zwick@scripps.edu (MBZ); robert.whalen@altravax.com (RGW)

Affiliation Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, United States of America
⨯
Robert G. Whalen

* E-mail: zwick@scripps.edu (MBZ); robert.whalen@altravax.com (RGW)

Affiliations Department of Infectious Diseases, Maxygen, Inc., Redwood City, California, United States of America, Altravax, Inc., Sunnyvale, California, United States of America
⨯

Prime-Boost Immunization of Rabbits with HIV-1 gp120 Elicits Potent Neutralization Activity against a Primary Viral Isolate

Kristin M. Narayan,
Nitish Agrawal,
Sean X. Du,
Janelle E. Muranaka,
Katherine Bauer,
Daniel P. Leaman,
Pham Phung,
Kay Limoli,
Helen Chen,
Rebecca I. Boenig

Published: January 9, 2013
https://doi.org/10.1371/journal.pone.0052732

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