Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation

Anushree Bhatnagar; Hamiyet Unal; Rajaganapathi Jagannathan; Suma Kaveti; Zhong-Hui Duan; Sandro Yong; Amit Vasanji; Michael Kinter; Russell Desnoyer; Sadashiva S. Karnik

doi:10.1371/journal.pone.0052689

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Peer-reviewed

Research Article

Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation

Anushree Bhatnagar,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Hamiyet Unal,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Rajaganapathi Jagannathan,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Suma Kaveti,

Affiliation Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Zhong-Hui Duan,

Affiliations Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Computer Science, University of Akron, Akron, Ohio, United States of America
⨯
Sandro Yong,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Amit Vasanji,

Affiliation Biomedical Imaging and Analysis Core, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Michael Kinter,

Affiliation Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Russell Desnoyer,

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯
Sadashiva S. Karnik

* E-mail: karniks@ccf.org

Affiliation Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
⨯

Interaction of G-Protein βγ Complex with Chromatin Modulates GPCR-Dependent Gene Regulation

Anushree Bhatnagar,
Hamiyet Unal,
Rajaganapathi Jagannathan,
Suma Kaveti,
Zhong-Hui Duan,
Sandro Yong,
Amit Vasanji,
Michael Kinter,
Russell Desnoyer,
Sadashiva S. Karnik

Published: January 9, 2013
https://doi.org/10.1371/journal.pone.0052689

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G protein coupled receptors
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Gene regulation
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Histones
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Gene expression
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Chromatin
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Genetic networks
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Proteomes
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DNA transcription
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