The Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis

Klaartje van Engelen; Mathilda T. M. Mommersteeg; Marieke J. H. Baars; Jan Lam; Aho Ilgun; A. S. Paul van Trotsenburg; Anne M. J. B. Smets; Vincent M. Christoffels; Barbara J. M. Mulder; Alex V. Postma

doi:10.1371/journal.pone.0052685

Loading metrics

Open Access

Peer-reviewed

Research Article

The Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis

Klaartje van Engelen ,

* E-mail: k.vanengelen@amc.uva.nl

Affiliations Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands, Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands (ICIN), Utrecht, The Netherlands
⨯
Mathilda T. M. Mommersteeg,

Current address: Department of Cell & Developmental Biology, University College London, London, United Kingdom

Affiliation Heart Failure Research Centre, Department of Anatomy and Embryology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Marieke J. H. Baars,

Affiliation Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
⨯
Jan Lam,

Affiliation Department of Pediatric Cardiology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Aho Ilgun,

Affiliation Heart Failure Research Centre, Department of Anatomy and Embryology, Academic Medical Center, Amsterdam, The Netherlands
⨯
A. S. Paul van Trotsenburg,

Affiliation Department of Pediatric Endocrinology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Anne M. J. B. Smets,

Affiliation Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Vincent M. Christoffels,

Affiliation Heart Failure Research Centre, Department of Anatomy and Embryology, Academic Medical Center, Amsterdam, The Netherlands
⨯
Barbara J. M. Mulder,

Affiliations Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands (ICIN), Utrecht, The Netherlands
⨯
Alex V. Postma

Affiliation Heart Failure Research Centre, Department of Anatomy and Embryology, Academic Medical Center, Amsterdam, The Netherlands
⨯

The Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis

Klaartje van Engelen,
Mathilda T. M. Mommersteeg,
Marieke J. H. Baars,
Jan Lam,
Aho Ilgun,
A. S. Paul van Trotsenburg,
Anne M. J. B. Smets,
Vincent M. Christoffels,
Barbara J. M. Mulder,
Alex V. Postma

Published: December 28, 2012
https://doi.org/10.1371/journal.pone.0052685

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Thyroid
Is the Subject Area "Thyroid" applicable to this article?

Thanks for your feedback.
Congenital heart defects
Is the Subject Area "Congenital heart defects" applicable to this article?

Thanks for your feedback.
Hypothyroidism
Is the Subject Area "Hypothyroidism" applicable to this article?

Thanks for your feedback.
Ventricular septal defects
Is the Subject Area "Ventricular septal defects" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
HeLa cells
Is the Subject Area "HeLa cells" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.