Nicorandil Prevents Gαq-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

Masamichi Hirose; Yasuchika Takeishi; Tsutomu Nakada; Hisashi Shimojo; Toshihide Kashihara; Ayako Nishio; Satoshi Suzuki; Ulrike Mende; Kiyoshi Matsumoto; Naoko Matsushita; Eiichi Taira; Fumika Sato; Mitsuhiko Yamada

doi:10.1371/journal.pone.0052667

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Open Access

Peer-reviewed

Research Article

Nicorandil Prevents Gα_q-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

Masamichi Hirose ,

* E-mail: mhirose@iwate-med.ac.jp

Affiliation Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan
⨯
Yasuchika Takeishi,

Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan
⨯
Tsutomu Nakada,

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
⨯
Hisashi Shimojo,

Affiliation Department of Pathology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
⨯
Toshihide Kashihara,

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
⨯
Ayako Nishio,

Affiliation The Research Center for Human and Environmental Science, Shinshu University, Matsumoto, Nagano, Japan
⨯
Satoshi Suzuki,

Affiliation Department of Cardiology and Hematology, Fukushima Medical University, Fukushima, Fukushima, Japan
⨯
Ulrike Mende,

Affiliation Cardiovascular Research Center, Division of Cardiology, Rhode Island Hospital & The Alpert Medical School of Brown University, Providence, Rhode Island, United States of America
⨯
Kiyoshi Matsumoto,

Affiliation The Research Center for Human and Environmental Science, Shinshu University, Matsumoto, Nagano, Japan
⨯
Naoko Matsushita,

Affiliation Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan
⨯
Eiichi Taira,

Affiliation Department of Pharmacology, Iwate Medical University School of Medicine, Shiwa, Iwate, Japan
⨯
Fumika Sato,

Affiliation Department of Molecular and Cellular Pharmacology, Iwate Medical University School of Pharmaceutical Sciences, Shiwa, Iwate, Japan
⨯
Mitsuhiko Yamada

Affiliation Department of Molecular Pharmacology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
⨯

Nicorandil Prevents Gα_q-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

Masamichi Hirose,
Yasuchika Takeishi,
Tsutomu Nakada,
Hisashi Shimojo,
Toshihide Kashihara,
Ayako Nishio,
Satoshi Suzuki,
Ulrike Mende,
Kiyoshi Matsumoto,
Naoko Matsushita

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0052667

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