Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Hema Dave; Miriam R. Anver; Donna O. Butcher; Patrick Brown; Javed Khan; Alan S. Wayne; Sivasubramanian Baskar; Christoph Rader

doi:10.1371/journal.pone.0052655

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Research Article

Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Hema Dave,

Affiliations Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Miriam R. Anver,

Affiliation Pathology/Histotechnology Laboratory, Science Applications International Corporation–Frederick, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
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Donna O. Butcher,

Affiliation Pathology/Histotechnology Laboratory, Science Applications International Corporation–Frederick, Frederick National Laboratory for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland, United States of America
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Patrick Brown,

Affiliation Department of Oncology and Pediatrics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Hospital, Baltimore, Maryland, United States of America
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Javed Khan,

Affiliation Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Alan S. Wayne,

Affiliations Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Sivasubramanian Baskar,

Affiliation Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Christoph Rader

* E-mail: crader@scripps.edu

Affiliations Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Cancer Biology and Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida, United States of America
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Restricted Cell Surface Expression of Receptor Tyrosine Kinase ROR1 in Pediatric B-Lineage Acute Lymphoblastic Leukemia Suggests Targetability with Therapeutic Monoclonal Antibodies

Hema Dave,
Miriam R. Anver,
Donna O. Butcher,
Patrick Brown,
Javed Khan,
Alan S. Wayne,
Sivasubramanian Baskar,
Christoph Rader

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0052655

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