Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage

Fei Yu; Bao-ying Li; Xiao-li Li; Qian Cai; Zhen Zhang; Mei Cheng; Mei Yin; Jun-fu Wang; Jian-hua Zhang; Wei-da Lu; Rui-hai Zhou; Hai-qing Gao

doi:10.1371/journal.pone.0052541

Loading metrics

Open Access

Peer-reviewed

Research Article

Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage

Fei Yu,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Bao-ying Li,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Xiao-li Li,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Qian Cai,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Zhen Zhang,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Mei Cheng,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Mei Yin,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Jun-fu Wang,

Affiliation Institute of Basic Science, Medical Science Academy of Shandong, Jinan, China
⨯
Jian-hua Zhang,

Affiliation Institute of Basic Science, Medical Science Academy of Shandong, Jinan, China
⨯
Wei-da Lu,

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯
Rui-hai Zhou,

Affiliation Division of Cardiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Hai-qing Gao

* E-mail: gaohaiqingdr@yahoo.com.cn

Affiliation Key Laboratory of Cardiovascular Proteomics of Shandong Province, Department of Geriatrics, Qi-Lu Hospital of Shandong University, Jinan, China
⨯

Proteomic Analysis of Aorta and Protective Effects of Grape Seed Procyanidin B2 in db/db Mice Reveal a Critical Role of Milk Fat Globule Epidermal Growth Factor-8 in Diabetic Arterial Damage

Fei Yu,
Bao-ying Li,
Xiao-li Li,
Qian Cai,
Zhen Zhang,
Mei Cheng,
Mei Yin,
Jun-fu Wang,
Jian-hua Zhang,
Wei-da Lu

Published: December 21, 2012
https://doi.org/10.1371/journal.pone.0052541

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Aorta
Is the Subject Area "Aorta" applicable to this article?

Thanks for your feedback.
Diabetes mellitus
Is the Subject Area "Diabetes mellitus" applicable to this article?

Thanks for your feedback.
RNA interference
Is the Subject Area "RNA interference" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Endothelial cells
Is the Subject Area "Endothelial cells" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Atherosclerosis
Is the Subject Area "Atherosclerosis" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.