Vitamin E δ-Tocotrienol Induces p27Kip1-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism

Pamela J. Hodul; Yanbin Dong; Kazim Husain; Jose M. Pimiento; Jiandong Chen; Anying Zhang; Rony Francois; Warren J. Pledger; Domenico Coppola; Said M. Sebti; Dung-Tsa Chen; Mokenge P. Malafa

doi:10.1371/journal.pone.0052526

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Open Access

Peer-reviewed

Research Article

Vitamin E δ-Tocotrienol Induces p27^Kip1-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism

Pamela J. Hodul,

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Yanbin Dong,

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Kazim Husain,

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Jose M. Pimiento,

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Jiandong Chen,

Affiliation Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Anying Zhang,

Affiliation School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China
⨯
Rony Francois,

Affiliation College of Medicine, University of Florida, Gainesville, Florida, United States of America
⨯
Warren J. Pledger,

Affiliation Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Domenico Coppola,

Affiliation Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Said M. Sebti,

Affiliation Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Dung-Tsa Chen,

Affiliation Biostatistics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯
Mokenge P. Malafa

* E-mail: mokenge.malafa@moffitt.org

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
⨯

Vitamin E δ-Tocotrienol Induces p27^Kip1-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism

Pamela J. Hodul,
Yanbin Dong,
Kazim Husain,
Jose M. Pimiento,
Jiandong Chen,
Anying Zhang,
Rony Francois,
Warren J. Pledger,
Domenico Coppola,
Said M. Sebti

Published: February 5, 2013
https://doi.org/10.1371/journal.pone.0052526

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