Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

Jianmei Gu; Hui Qian; Li Shen; Xu Zhang; Wei Zhu; Ling Huang; Yongmin Yan; Fei Mao; Chonghui Zhao; Yunyan Shi; Wenrong Xu

doi:10.1371/journal.pone.0052465

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Open Access

Peer-reviewed

Research Article

Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

Jianmei Gu ,

Contributed equally to this work with: Jianmei Gu, Hui Qian

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Hui Qian ,

Contributed equally to this work with: Jianmei Gu, Hui Qian

* E-mail: icls@ujs.edu.cn (WX); lstmmmlst@163.com (HQ)

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Li Shen,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Xu Zhang,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Wei Zhu,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Ling Huang,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Yongmin Yan,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Fei Mao,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Chonghui Zhao,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Yunyan Shi,

Affiliation School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China
⨯
Wenrong Xu

* E-mail: icls@ujs.edu.cn (WX); lstmmmlst@163.com (HQ)

Affiliations School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, Jiangsu, China, Department of Clinical Laboratory Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China
⨯

Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway

Jianmei Gu,
Hui Qian,
Li Shen,
Xu Zhang,
Wei Zhu,
Ling Huang,
Yongmin Yan,
Fei Mao,
Chonghui Zhao,
Yunyan Shi

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0052465

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Exosomes
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Gastric cancer
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