CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Fernando L. Martin; S. Jeson Sangaralingham; Brenda K. Huntley; Paul M. McKie; Tomoko Ichiki; Horng H. Chen; Josef Korinek; Gerald E. Harders; John C. Burnett Jr

doi:10.1371/journal.pone.0052422

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Open Access

Peer-reviewed

Research Article

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Fernando L. Martin ,

Contributed equally to this work with: Fernando L. Martin, S. Jeson Sangaralingham

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
S. Jeson Sangaralingham ,

Contributed equally to this work with: Fernando L. Martin, S. Jeson Sangaralingham

* E-mail: sangaralingham.jeson@mayo.edu

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Brenda K. Huntley,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Paul M. McKie,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Tomoko Ichiki,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Horng H. Chen,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Josef Korinek,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gerald E. Harders,

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
John C. Burnett Jr

Affiliation Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, United States of America
⨯

CD-NP: A Novel Engineered Dual Guanylyl Cyclase Activator with Anti-Fibrotic Actions in the Heart

Fernando L. Martin,
S. Jeson Sangaralingham,
Brenda K. Huntley,
Paul M. McKie,
Tomoko Ichiki,
Horng H. Chen,
Josef Korinek,
Gerald E. Harders,
John C. Burnett Jr

Published: December 18, 2012
https://doi.org/10.1371/journal.pone.0052422

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