Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

Sander S. Rensen; Veerle Bieghs; Sofia Xanthoulea; Evi Arfianti; Jaap A. Bakker; Ronit Shiri-Sverdlov; Marten H. Hofker; Jan Willem Greve; Wim A. Buurman

doi:10.1371/journal.pone.0052411

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Open Access

Peer-reviewed

Research Article

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

Sander S. Rensen ,

* E-mail: s.rensen@maastrichtuniversity.nl

Affiliation Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Veerle Bieghs,

Affiliation Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Sofia Xanthoulea,

Affiliation Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Evi Arfianti,

Current address: Department of Medical Biology, Riau University, Pekanbaru, Indonesia

Affiliation Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Jaap A. Bakker,

Affiliation Department of Clinical Genetics, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Ronit Shiri-Sverdlov,

Affiliation Department of Genetics and Cell Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯
Marten H. Hofker,

Affiliation Department of Pathology & Medical Biology, Medical Biology Section, Molecular Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
⨯
Jan Willem Greve,

Affiliations Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands, Department of Surgery, Atrium Medical Center Parkstad, Heerlen, The Netherlands
⨯
Wim A. Buurman

Affiliation Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
⨯

Neutrophil-Derived Myeloperoxidase Aggravates Non-Alcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Deficient Mice

Sander S. Rensen,
Veerle Bieghs,
Sofia Xanthoulea,
Evi Arfianti,
Jaap A. Bakker,
Ronit Shiri-Sverdlov,
Marten H. Hofker,
Jan Willem Greve,
Wim A. Buurman

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0052411

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