Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies

Patrycja J. Lech; Gregory J. Tobin; Ruth Bushnell; Emily Gutschenritter; Linh D. Pham; Rebecca Nace; Els Verhoeyen; François-Loïc Cosset; Claude P. Muller; Stephen J. Russell; Peter L. Nara

doi:10.1371/journal.pone.0052306

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Open Access

Peer-reviewed

Research Article

Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies

Patrycja J. Lech ,

* E-mail: Lech.patrycja@mayo.edu

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Gregory J. Tobin,

Affiliation Biological Mimetics, Inc., Frederick, Maryland, United States of America
⨯
Ruth Bushnell,

Affiliation Biological Mimetics, Inc., Frederick, Maryland, United States of America
⨯
Emily Gutschenritter,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Linh D. Pham,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Rebecca Nace,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Els Verhoeyen,

Affiliations INSERM, U758, Human Virology Laboratory, EVIR Team, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université de Lyon, UCB-Lyon1, Lyon, France
⨯
François-Loïc Cosset,

Affiliations INSERM, U758, Human Virology Laboratory, EVIR Team, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France, Université de Lyon, UCB-Lyon1, Lyon, France
⨯
Claude P. Muller,

Affiliation Department of Immunology and WHO Collaborating Center for Reference and Research on Measles Infections, Centre de Recherche Public de la Santé/Laboratoire National de Santé, Luxembourg, Luxembourg
⨯
Stephen J. Russell,

Affiliation Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
⨯
Peter L. Nara

Affiliations Biological Mimetics, Inc., Frederick, Maryland, United States of America, College of Veterianty Medicine, Iowa State University, Ames, Iowa, United States of America
⨯

Epitope Dampening Monotypic Measles Virus Hemagglutinin Glycoprotein Results in Resistance to Cocktail of Monoclonal Antibodies

Patrycja J. Lech,
Gregory J. Tobin,
Ruth Bushnell,
Emily Gutschenritter,
Linh D. Pham,
Rebecca Nace,
Els Verhoeyen,
François-Loïc Cosset,
Claude P. Muller,
Stephen J. Russell

Published: January 3, 2013
https://doi.org/10.1371/journal.pone.0052306

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