Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer

Ying Li; Yongwen Li; Tong Yang; Sen Wei; Jing Wang; Min Wang; Yuli Wang; Qinghua Zhou; Hongyu Liu; Jun Chen

doi:10.1371/journal.pone.0052093

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Open Access

Peer-reviewed

Research Article

Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer

Ying Li ,

Contributed equally to this work with: Ying Li, Yongwen Li, Tong Yang

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Yongwen Li ,

Contributed equally to this work with: Ying Li, Yongwen Li, Tong Yang

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Tong Yang ,

Contributed equally to this work with: Ying Li, Yongwen Li, Tong Yang

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Sen Wei,

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Jing Wang,

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Min Wang,

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Yuli Wang,

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Qinghua Zhou ,

* E-mail: zhouqh1016@yahoo.com.cn (QZ); liuhongyu123@hotmail.com (HL); huntercj2004@yahoo.com (JC)

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Hongyu Liu ,

* E-mail: zhouqh1016@yahoo.com.cn (QZ); liuhongyu123@hotmail.com (HL); huntercj2004@yahoo.com (JC)

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯
Jun Chen

* E-mail: zhouqh1016@yahoo.com.cn (QZ); liuhongyu123@hotmail.com (HL); huntercj2004@yahoo.com (JC)

Affiliation Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Heping District, Tianjin, China
⨯

Clinical Significance of EML4-ALK Fusion Gene and Association with EGFR and KRAS Gene Mutations in 208 Chinese Patients with Non-Small Cell Lung Cancer

Ying Li,
Yongwen Li,
Tong Yang,
Sen Wei,
Jing Wang,
Min Wang,
Yuli Wang,
Qinghua Zhou,
Hongyu Liu,
Jun Chen

Published: January 14, 2013
https://doi.org/10.1371/journal.pone.0052093

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Non-small cell lung cancer
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Lung and intrathoracic tumors
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Reverse transcriptase-polymerase chain reaction
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Fusion genes
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