Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

Anton K. Raap; Roshan S. Jahangir Tafrechi; Frans M. van de Rijke; Angela Pyle; Carolina Wählby; Karoly Szuhai; Raimond B. G. Ravelli; René F. M. de Coo; Harsha K. Rajasimha; Mats Nilsson; Patrick F. Chinnery; David C. Samuels; George M. C. Janssen

doi:10.1371/journal.pone.0052080

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Open Access

Peer-reviewed

Research Article

Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

Anton K. Raap,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Roshan S. Jahangir Tafrechi,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Frans M. van de Rijke,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Angela Pyle,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Carolina Wählby,

Affiliations Imaging Platform, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America, Centre for Image Analysis, Uppsala University, Uppsala, Sweden
⨯
Karoly Szuhai,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Raimond B. G. Ravelli,

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
René F. M. de Coo,

Affiliation Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
⨯
Harsha K. Rajasimha,

Affiliation Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Mats Nilsson,

Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
⨯
Patrick F. Chinnery,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
David C. Samuels,

Affiliation Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
George M. C. Janssen

* E-mail: g.m.c.janssen@lumc.nl

Current address: Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands

Affiliation Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands
⨯

Non-Random mtDNA Segregation Patterns Indicate a Metastable Heteroplasmic Segregation Unit in m.3243A>G Cybrid Cells

Anton K. Raap,
Roshan S. Jahangir Tafrechi,
Frans M. van de Rijke,
Angela Pyle,
Carolina Wählby,
Karoly Szuhai,
Raimond B. G. Ravelli,
René F. M. de Coo,
Harsha K. Rajasimha,
Mats Nilsson

Published: December 18, 2012
https://doi.org/10.1371/journal.pone.0052080

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