Intramyocardial Delivery of Mesenchymal Stem Cell-Seeded Hydrogel Preserves Cardiac Function and Attenuates Ventricular Remodeling after Myocardial Infarction

Eva Mathieu; Guillaume Lamirault; Claire Toquet; Pierre Lhommet; Emilie Rederstorff; Sophie Sourice; Kevin Biteau; Philippe Hulin; Virginie Forest; Pierre Weiss; Jérôme Guicheux; Patricia Lemarchand

doi:10.1371/journal.pone.0051991

Loading metrics

Open Access

Peer-reviewed

Research Article

Intramyocardial Delivery of Mesenchymal Stem Cell-Seeded Hydrogel Preserves Cardiac Function and Attenuates Ventricular Remodeling after Myocardial Infarction

Eva Mathieu,

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France
⨯
Guillaume Lamirault,

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France
⨯
Claire Toquet,

Affiliations CHU de Nantes, Nantes, France, Service d’Anatomie Pathologique, E.A. Biometadys, CHU de Nantes, Nantes, France
⨯
Pierre Lhommet,

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France
⨯
Emilie Rederstorff,

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France
⨯
Sophie Sourice,

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France
⨯
Kevin Biteau,

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France
⨯
Philippe Hulin,

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, Cellular and Tissular Imaging Core Facility of Nantes University (MicroPICell), Nantes, France
⨯
Virginie Forest,

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France
⨯
Pierre Weiss,

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France
⨯
Jérôme Guicheux ,

Contributed equally to this work with: Jérôme Guicheux, Patricia Lemarchand

Affiliations Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, INSERM, U791, Laboratory of Osteo-Articular and Dental Tissue Engineering, Group STEP “Skeletal tissue Engineering and Physiopathology”, Nantes, France
⨯
Patricia Lemarchand

Contributed equally to this work with: Jérôme Guicheux, Patricia Lemarchand

* E-mail: patricia.lemarchand@univ-nantes.fr

Affiliations INSERM UMR1087, CNRS UMR6291, l’institut du thorax, Nantes, France, Université de Nantes, Structure Fédérative de Recherche Santé F. Bonamy, Nantes, France, CHU de Nantes, Nantes, France
⨯

Intramyocardial Delivery of Mesenchymal Stem Cell-Seeded Hydrogel Preserves Cardiac Function and Attenuates Ventricular Remodeling after Myocardial Infarction

Eva Mathieu,
Guillaume Lamirault,
Claire Toquet,
Pierre Lhommet,
Emilie Rederstorff,
Sophie Sourice,
Kevin Biteau,
Philippe Hulin,
Virginie Forest,
Pierre Weiss

Published: December 20, 2012
https://doi.org/10.1371/journal.pone.0051991

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gels
Is the Subject Area "Gels" applicable to this article?

Thanks for your feedback.
Myocardial infarction
Is the Subject Area "Myocardial infarction" applicable to this article?

Thanks for your feedback.
Mesenchymal stem cells
Is the Subject Area "Mesenchymal stem cells" applicable to this article?

Thanks for your feedback.
Cardiovascular physiology
Is the Subject Area "Cardiovascular physiology" applicable to this article?

Thanks for your feedback.
Myocardium
Is the Subject Area "Myocardium" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Echocardiography
Is the Subject Area "Echocardiography" applicable to this article?

Thanks for your feedback.
Medical implants
Is the Subject Area "Medical implants" applicable to this article?

Thanks for your feedback.