Reorienting the Fab Domains of Trastuzumab Results in Potent HER2 Activators

• Justin M. Scheer ,

  * E-mail: scheer.justin@gene.com

  Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

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• Wendy Sandoval,

  Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

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• J. Michael Elliott,

  Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

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• Lily Shao,

  Affiliation Department of Research Oncology, Genentech Inc., South San Francisco, California, United States of America

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• Elizabeth Luis,

  Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

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• Sock-Cheng Lewin-Koh,

  Affiliation Department of Biostatistics, Genentech Inc., South San Francisco, California, United States of America

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• Gabriele Schaefer,

  Affiliation Department of Research Oncology, Genentech Inc., South San Francisco, California, United States of America

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• Richard Vandlen

  Affiliation Department of Protein Chemistry, Genentech Inc., South San Francisco, California, United States of America

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