Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

Tjinta Brinkhuizen; Karin van den Hurk; Véronique J. L. Winnepenninckx; Joep P. de Hoon; Ariënne M. van Marion; Jürgen Veeck; Manon van Engeland; Maurice A. M. van Steensel

doi:10.1371/journal.pone.0051710

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Open Access

Peer-reviewed

Research Article

Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

Tjinta Brinkhuizen ,

* E-mail: t.brinkhuizen@mumc.nl

Affiliations Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
⨯
Karin van den Hurk,

Affiliations Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
⨯
Véronique J. L. Winnepenninckx,

Affiliations Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
⨯
Joep P. de Hoon,

Affiliations Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands, Department of Internal Medicine (Division of Medical Oncology), Maastricht University Medical Center, Maastricht, The Netherlands
⨯
Ariënne M. van Marion,

Affiliation Department of Pathology, VieCuri Medical Centre, Venlo, The Netherlands
⨯
Jürgen Veeck,

Affiliations Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands, Department of Internal Medicine (Division of Medical Oncology), Maastricht University Medical Center, Maastricht, The Netherlands, Institute of Pathology, University Hospital of the RWTH Aachen, Aachen, Germany
⨯
Manon van Engeland,

Affiliations Department of Pathology, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
⨯
Maurice A. M. van Steensel

Affiliations Department of Dermatology, Maastricht University Medical Center, Maastricht, The Netherlands, Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
⨯

Epigenetic Changes in Basal Cell Carcinoma Affect SHH and WNT Signaling Components

Tjinta Brinkhuizen,
Karin van den Hurk,
Véronique J. L. Winnepenninckx,
Joep P. de Hoon,
Ariënne M. van Marion,
Jürgen Veeck,
Manon van Engeland,
Maurice A. M. van Steensel

Published: December 17, 2012
https://doi.org/10.1371/journal.pone.0051710

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DNA methylation
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Basal cell carcinomas
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Antigen-presenting cells
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Malignant tumors
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Epigenetics
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Tumor suppressor genes
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Wnt signaling cascade
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Polymerase chain reaction
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