Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

Nirmala Hariharan; Yoshiyuki Ikeda; Chull Hong; Ralph R. Alcendor; Soichiro Usui; Shumin Gao; Yasuhiro Maejima; Junichi Sadoshima

doi:10.1371/journal.pone.0051632

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Peer-reviewed

Research Article

Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

Nirmala Hariharan,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
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Yoshiyuki Ikeda,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Chull Hong,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
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Ralph R. Alcendor,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
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Soichiro Usui,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Shumin Gao,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Yasuhiro Maejima,

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯
Junichi Sadoshima

* E-mail: sadoshju@umdnj.edu

Affiliation Department of Cell Biology and Molecular Medicine, Cardiovascular Research Institute, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, New Jersey, United States of America
⨯

Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

Nirmala Hariharan,
Yoshiyuki Ikeda,
Chull Hong,
Ralph R. Alcendor,
Soichiro Usui,
Shumin Gao,
Yasuhiro Maejima,
Junichi Sadoshima

Published: January 7, 2013
https://doi.org/10.1371/journal.pone.0051632

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Autophagic cell death
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Cardiac hypertrophy
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Cardiomyocytes
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Heart
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Genetically modified animals
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Hyperexpression techniques
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