Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Francesca Cavallo; Grazia Graziani; Cristina Antinozzi; Darren R. Feldman; Jane Houldsworth; George J. Bosl; Raju S. K. Chaganti; Mary Ellen Moynahan; Maria Jasin; Marco Barchi

doi:10.1371/journal.pone.0051563

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Research Article

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Francesca Cavallo,

Affiliations Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy, Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Grazia Graziani,

Affiliation Department of System Medicine, University of Rome Tor Vergata, Rome, Italy
⨯
Cristina Antinozzi,

Affiliation Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
⨯
Darren R. Feldman,

Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Jane Houldsworth,

Affiliation Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
George J. Bosl,

Affiliation Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Raju S. K. Chaganti,

Affiliation Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Mary Ellen Moynahan,

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Maria Jasin,

Affiliation Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
⨯
Marco Barchi

* E-mail: marco.barchi@uniroma2.it

Affiliation Department of Biomedicine and Prevention, Section of Anatomy, University of Rome Tor Vergata, Rome, Italy
⨯

Reduced Proficiency in Homologous Recombination Underlies the High Sensitivity of Embryonal Carcinoma Testicular Germ Cell Tumors to Cisplatin and Poly (ADP-Ribose) Polymerase Inhibition

Francesca Cavallo,
Grazia Graziani,
Cristina Antinozzi,
Darren R. Feldman,
Jane Houldsworth,
George J. Bosl,
Raju S. K. Chaganti,
Mary Ellen Moynahan,
Maria Jasin,
Marco Barchi

Published: December 12, 2012
https://doi.org/10.1371/journal.pone.0051563

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